Health And Wellness Tips & Information

Which Is Better Prilosec, Nexium or Prevacid?

If you are one of the millions of people who suffer from acid reflux you are certainly looking for a solution. There are many OTC options but which one works best? This article looks at the 3 most popular OTC options. You should always consult your personal physician prior to using any acid reflux remedies.

Nexium, Prilosec, Prevacid, OTC acid reflux options

OTC acid reflux treatment options

Which OTC Acid Reflux Options Works Best?


If you are over the age of 40, it is likely that you have experienced acid reflux. There are multiple options to treat your acid reflux but which is best? This article makes an attempt to educate you on the 3 most popular options.

First, lets’ look at the ways Prilosec, Nexium and Prevacid are similar. All three are part of the PPI family of acid reflux treatments. PPI stands for Proton Pump Inhibitor. This family of medicines in considered by most medical professionals as the #1 treatment option for acid reflux, GERD or heartburn.

The way that PPIs work is simply by turning off the acid pumps in your stomach. This reduces the acidity inside of your stomach and will elevate your pH levels. All of them are extremely easy to use and are effective with a single daily dose. They all are tolerated very well when used for less than 14 days.

Which is “better?”

Better is an interesting word. It is most certainly subjective and there are a multitude of factor that need to be considered. For some people faster is better while to others longer lasting relief is the goal. Individual body chemistry impacts both of these.

Pharmacogenomics is the study of how our individual genes react in response to a drug. Trial and error is the best way to determine which OTC medication is best for you, especially when discussing PPI drugs.  Still there is value in looking at studies which compare these 3 drugs.

Comparative Studies

There have been two studies which compare Prilosec vs. Nexium. Based on these studies, Nexium has been shown to offer more effective and broader range of acid control than does Prilosec. The range of effectiveness seems to be less with Nexium than Prilosec withing any individual’s experience. So the overall effectiveness of Nexium, based on these studies, is greater than Prilosec.

The same seems to hold true, based on additional studies, when Nexium is compared to Prevacid. However Prevacid has a more rapid achievement of maximum acid suppression than do the other two PPI medications. This means that Prevacid will achieve a quicker level of it’s maximum relief.


So while we would like to make a final and certain recommendation for one of the 3 OTC acid relief drugs we really can’t. We can say that all of them are effective and do so in a safe manner. We would suggest that you research each. You should work in concert with the advice and consent of your physician and determine which works best for you individual situation.


Pharmacist Answers: Prilosec vs Nexium vs Prevacid what is the difference

Consumer Reports – PPI Drug Review